| Compounds | Topics | Title | Date |
|---|---|---|---|
| cannabis | adolescent use via review | The Harm of Cannabis in Adolescents | Jun 2019 |
| Negative The use of cannabis in adolescents is associated with poor physical health status, poor performance at school, decreased academic achievement and an increase in the likelihood for dropout. | |||
| cannabis | adolescent use,depression via review | Effects of Adolescent Cannabis Use on Motivation and Depression: a Systematic Review | Aug 2019 |
| Heavy adolescent cannabis use is associated with poorer educational outcomes and increased levels of depressive symptoms. The role of depression in how cannabis may affect motivation, broadly, is not yet clear, as most studies have not examined associations among all three constructs. | |||
| cannabis | adolescent use in humans via study (n=1989) | Associations between Adolescent Cannabis Use and Neuropsychological Decline: A Longitudinal Co-Twin Control Study | Feb 2018 |
| Negative Compared with adolescents who did not use cannabis, adolescents who used cannabis had lower IQ in childhood, prior to cannabis initiation, and had lower IQ at age 18, but there was little evidence that cannabis use was associated with IQ decline from age 12-18. | |||
| THC | adolescent use in rats | Adolescent exposure to delta-9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons | Oct 2018 |
| Overall, adolescent THC exposure altered the morphological and transcriptional trajectory of PFC pyramidal neurons, which could enhance vulnerability to psychiatric disorders. | |||
| cannabis | adolescent use via review | Medical Cannabinoids in Children and Adolescents: A Systematic Review. | Nov 2017 |
| Evidence for benefit was strongest for chemotherapy-induced nausea and vomiting, with increasing evidence of benefit for epilepsy. At this time, there is insufficient evidence to support use for spasticity, neuropathic pain, posttraumatic stress disorder, and Tourette syndrome. | |||
| cannabis | adolescent use in mice | Adolescent delta-9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-kappa-B-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood | Jun 2019 |
| The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of delta-9-tetrahydrocannabinol (delta-9-THC), a cannabis constituent and partial agonist of brain cannabinoid receptor 1 | |||
| WIN55 | adolescent use in mice via placebo trial | Behavioral effects of chronic WIN 55,212-2 administration during adolescence and adulthood in mice. | May 2019 |
|
Ingestion Method: 3.0 mg/kg/day WIN 55,212-2 For the reversal-learning task, there was no difference in errors or omissions to criterion following a reversal in adolescent-exposed mice but adult-exposed mice showed a delay in beginning the reversal, suggesting that adolescents, but not adults, are resilient to this drug. Adult mice given WIN 55,212-2 in adolescence displayed greater impulsivity in the form of preference for smaller-sooner reinforcers over larger-delayed ones in the delay-discounting procedure, but this was seen to a lesser extent with adult-onset exposure. | |||
| cannabis | adolescent use in humans via study (n=1000) | Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood. | Sep 2019 |
| Adolescent cannabis use is not associated with structural brain differences in adulthood. | |||
| cannabis | adolescent use in humans via study (n=94035) | Cannabis use and leisure-time sedentary behavior among 94,035 adolescents aged 12-15 years from 24 low- and middle-income countries | Aug 2019 |
| 2.8% of the adolescents in low- and middle-income countries used cannabis at least once in the past 30 days | |||
| cannabis | adolescent use in humans via study (n=644) | Prospective Analysis of Prevalence, Trajectories of Change, and Correlates of Cannabis Misuse in Older Adolescents from Coastal Touristic Regions in Croatia. | Aug 2019 |
| Quitting sports was a risk factor for CC at baseline and follow-up. Better sport competitive results (odds ratio (OR): 0.80, 95% confidence interval (CI): 0.65-0.96) and familial social status (socioeconomic status: OR: 0.66, 95% CI: 0.39-0.91; maternal education: OR: 0.65, 95% CI: 0.48-0.88) were associated with lower likelihood of CC at baseline. | |||
| cannabis | adolescent use in humans via study (n=401) | Adolescent cannabis use and its associations with decision-making and episodic memory: Preliminary results from a longitudinal study. | Jul 2019 |
| Our findings suggest that poorer decision-making does not put teens at relatively early stages of cannabis use at risk for further escalation in use over one year. However, increasing cannabis use over the same period was associated with declines in immediate memory. | |||